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A few people have attempted such a model:

https://www.researchgate.net/publication/345753939_Outlines_...

https://zenodo.org/record/4477081

I don't fully agree with either analysis, but it shows the evidence and basic form of the argument. Most human pandemics historically have originated from natural zoonosis, but the 1977 flu pandemic was very likely a lab accident. So my prior knowing that a pandemic has occurred but nothing else would be small but not zero, perhaps a few percent.

That the pandemic occurred in a city that (a) lies far from expected natural spillover regions for SARS-like viruses, and (b) contains the lab with the world's biggest collection of SARS-like viruses increases that probability. That the lab staff say they weren't working with any viruses close to SARS-CoV-2 decreases it, but the obstruction of any attempt to verify that independently increases it back again.

The absence of a proximal host also increases that probability. China has every opportunity and motivation to find that, and so far they've failed. I guess it's possible that they found it and they're lying, because they seem determined now to show that the virus originated outside China; but the lab leak has become a sufficiently established part of (politicized and largely science-free) anti-China rhetoric that I'd guess they'd welcome the chance to prove it false.

Of course that could just mean the pandemic originated from a very rare but natural event. But that then raises the possibility of a naturally-evolved virus released by WIV staff, whether by way of the lab or just from a researcher who gets infected on a sampling trip--WIV collection activity is a small fraction of total human activity in spillover areas, but a large fraction of human activity travelling from the most remote virus-rich regions back to Wuhan.

If you're interested in this, I'd suggest Alina Chan's Twitter feed. She's taken a tremendous reputational risk here, and quite a lot of abuse both from virologists who find it unthinkable that their work could lead to such a catastrophe, and from genuine conspiracy theorists disappointed when what they thought was their ally debunks their science-free claims.




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