We have MBPs on our desks but our cloud are Centos Xeon machines. The problems I run into are not squeezing every last ms of performance, since it's vastly cheaper to just add more instances. The problems I care about is that some script I wrote suddenly doesn't work in production because of BSDisms, or Python incompatibilities, or old packages in brew, etc. Would be nice if Apple waved a magic wand and replaced its BSD subsystem with Centos* but I won't be holding my breath :)

* yes I know Centos is done, substitute as needed.