Its also been shown not to have an effect in at least one RCT, but the problem is social media skews against spreading that information (its kind of a downer so it won't get shared so much)
(Yes, the RCT uses cholecalciferol instead of calcifediol, so the reason why the intervention did not work may be that its a bit late. Yes, the Spanish trial had extremely good results, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ but it looked unusual (100% adherence / no dropouts). Ultimately we still don't know, which is appalling. We need better ways to conduct RCTs cheaply and efficiently!)
I would totally take it, but I wouldn't be very surprised if I still got a severe disease.
My point is that its important for people to have an accurate picture of what is the probability of it working, to have a good "feel" of what the likelihood of a good outcome is. Unfortunately social media is providing a skewed picture.
I'm not sure what mechanism would ensure that people get an accurate picture.
https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v...
(Yes, the RCT uses cholecalciferol instead of calcifediol, so the reason why the intervention did not work may be that its a bit late. Yes, the Spanish trial had extremely good results, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ but it looked unusual (100% adherence / no dropouts). Ultimately we still don't know, which is appalling. We need better ways to conduct RCTs cheaply and efficiently!)