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Misguided Use of Hydroxychloroquine for Covid-19 (jamanetwork.com)
1 point by vanilla-almond on Nov 11, 2020 | hide | past | favorite | 2 comments


The study is flawed in the same way most other HCL studies are flawed: they use hospitalization as criteria for inclusion in the study. Waiting for hospitalization, indeed any delay, is an error.

The original (and current) protocols for hydroxychloroquine mandate HCL+ZINC+AZITHROMYCIN EARLY (within the first few days of symptoms). Early aggressive treatment stops the virus (and minimizes bacterial infection that otherwise might follow), whereas waiting until the lungs are severely damaged and clogged results in failure.

In this study, as in almost all others, doctors waited until patients were in severe respiratory distress before admitting them to the hospital and waited even further before they were admitted to the study and given treatment. From the article:

>"Design, Setting, and Participants... Adults hospitalized with respiratory symptoms from severe acute respiratory syndrome coronavirus 2 infection were enrolled ..."<

There is a difference between treatment within 1-3 days of occurrence and treatment 1-3 weeks after occurrence.


Why haven't we had a similar onslaught against remdesivir? (patented by one company)

https://www.sciencemag.org/news/2020/10/very-very-bad-look-r...

On HCQ (no patent; used for decades for malaria thus there's extensive clinical experience on its use) there are other views across the world. http://www.francesoir.fr/societe-sante/covid-19-hydroxychlor...

(IMO use of the word 'irrefutable' is not a wise choice. However the results are interesting.)




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