for one it sounds like then I would have to use Firefox more often, I like the Chrome interface more although I can concede the resource hogging has gotten annoying
for two, I don't know anything about Firefox profiles, does that create a profile for my extensions too? Will multiple firefox profiles have different metamask instances segregated?
I've been using this combo for a while and it works really well. I have 2-4 profiles open at one time and just whitelist my inbox and a few other sites/apps I frequent while working. Great Suspender makes it totally viable.
I've started using them recently to have entirely seperate environments for personal and work websites and it's a blessing. Previously I used 2 browsers just like you, now I have the unlimited power of Firefox AdBlockers in every environment.
Doesn't that just provide separation of cookies (and maybe cache)? If you want entirely separate environments (cookies, cache, bookmarks, history, extensions) I believe you need to use multiple profiles.