1) If ~10% of the population has already had it, and 30-40% have some pre-existing immunity in the form of useful, relevant corona antibodies, then 40-50% of the population doesn't need a vaccine at this point (until immunity wears off, whenever that is). I know that likely isn't the reasoning going into many people's decision making, but we shouldn't be surprised based solely off of the numbers.
2) Then there's studies like this one from 2012 about original SARS vaccine development (with almost a decade of research after the initial outbreak) that shows 4 completely different approaches to vaccination all made subsequent exposure to the virus worse.
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
We should be skeptical of a vaccine for any disease where one of the major complication risks is basically a form of autoimmune disease.
We don't want to encourage a strong autoimmune response when a major existing risk is an overly aggressive immune response.
This is a reason that steroids seem to be emerging as a beneficial treatment: they actually suppress immune system response.
I'm not suggesting an effective vaccine won't ever be developed, but we shouldn't judge people in what may be a valid concern. Even if they have different than the relevant reasons for that concern.
2) Then there's studies like this one from 2012 about original SARS vaccine development (with almost a decade of research after the initial outbreak) that shows 4 completely different approaches to vaccination all made subsequent exposure to the virus worse.
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335060/
We should be skeptical of a vaccine for any disease where one of the major complication risks is basically a form of autoimmune disease.
We don't want to encourage a strong autoimmune response when a major existing risk is an overly aggressive immune response.
This is a reason that steroids seem to be emerging as a beneficial treatment: they actually suppress immune system response.
I'm not suggesting an effective vaccine won't ever be developed, but we shouldn't judge people in what may be a valid concern. Even if they have different than the relevant reasons for that concern.