I've read all the arguments against the iTunes activation step, not many for to be fair, but I believe I represent the silent majority that just doesn't mind that imposition. The iPad is book matched with it's sync software, ipad owner will then continue to use their sync software because it provides all the access to the music, movies, photos, apps, ...
As I remember, my US Robotics palm pilot did work without the initial sync, but I wouldn't have like to have trusted my data without sync and backup.
What's your particular problem with the initial sync stage?
What's your particular problem with the initial sync stage?