theres actually a fair few things that do work with wine. any of the GUI stuff (although it looks a bit ugly), writing and reading to a file. menus. lots of other bits that i cant remember now.
but it only works with other programs that are running in wine so theres not a whole lot you can do with it at the same time. ive mostly been using it to process strings and that sort of thing.
ive been thinking i should try and make a list somewhere of what is working and what isnt. it would make it easier to test things every time there is a new version of wine released
i made a script for autokey that will run the selected file in wine when you press alt + r. if you download the portable version of autohotkey and add the path to it then you can use the same hotkey to run the a script