Interface is similar across the platforms; I had to do a few test streams on macOS before I could find settings that didn't cause streaming hiccups or problems with other software. I also had to make sure the OBS app interface was on a monitor separate from the one I was streaming; otherwise sometimes it would have some weird stuttering issues.

No matter what, you'll probably need to spend a little time tweaking things to get it all working like you want. But the 'scenes' and preferences are pretty good about letting you lock things down once you do find something you like.