I don't get what's so great about their interface. Sure it's got eye candy. But I can't even search for +- 1 day from my selected date. Most airline or travel sites can.
Yeah, that's a rather important feature, given that airlines often run certain flights only on certain days. I don't personally do much business travel, so when I fly, my dates are extremely flexible.
It also seems to completely lack EasyJet, which makes it nearly useless for intra-Europe flights.
I've seen quite a lot of Hipmunk hype, and it does have a nice UI that presents information well. But in terms of actually finding the cheapest flight in a given time window, I'll stick with Kayak.