Ibduilast, which is a drug that has been on the market in Japan and safely used for 30 years, has also been used to treat alcohol and opioid addiction.[1][2]

[1]https://www.nature.com/articles/npp201710?draft\\u003dcollec... [2]https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12261