If you're working on a cure for cancer you should have double, triple, quadruple backups on and off site and not fly around with the only copy of your data.
I bet GP meant it to ironic. That said, having a backup and knowing that the data was just corrupted are two different things. In a word without storage level CRC checks, it is possible an otherwise successful test is overlooked and we move on to 'n + 1' in the iteration.
But that said, hopefully all filesystems have some sort of error to show the file has been damaged.
" Cure to cancer lost to TSA scanner "