Very possible and future experiments should probe this hypothesis too. We should never forget that the very beginnings of immunotherapy were paradoxes themselves (e.g. infecting someone with a disease to control cancer). Our immune system, like many other complex non-linear systems, have been known to behave unpredictably at local levels while behaving predictably at a global level. If you have not already read it, this is a fascinating review of the paradoxical progress of modern immunotherapy (cancer centric) - https://www.sciencedirect.com/science/article/pii/S235230421...