My buddy had bad GI symptoms(throwing up, diarrhea). He also lost his adrenals and thyroid. His thyroid may come back, but he'll be on pills for the rest of his life. IIRC, the treatment lasted about 2 years. He had the advantage of being a guitarist by trade who lived at home anyway. I'm not sure how someone with a normal life would have made it through it. He was the only patient who made it all the way through the trial. He also smoked cigarettes and marijuana, and had a opioid habit. That said, he still managed to keep hiking a couple times a week except on his roughest chemo weeks.