I use a Pi-Hole and on top of that uBlock Origin. Seems a pretty nice combination. For privacy though, you need to know what level of privacy you're aiming for. At a certain point, adblockers and tracking protectors won't help and you're better of with something like Tor. For like, general daily use though, I very much recommend a Pi-Hole + uBlock Origin. Oh, and Firefox, not Chrome, for obvious privacy reasons.