so, this isn't for everyone, but I like the uBlock Origin + uMatrix combo.
This will break a lot at first, but uMatrix allows you to build a whitelist easily, and slowly over time website won't be broken half as much, and it'll be exceptionally rare for you to have to disable the whole extension whenever you want things to get working again.
The basic functionality of uMatrix is actually built into uBlock Origin. That's the setup I use. I have all 3rd party scripts and frames blocked by default and allow them on a per-site basis as required. After a while you get a sense for which domains need to be let through for a site to work
This will break a lot at first, but uMatrix allows you to build a whitelist easily, and slowly over time website won't be broken half as much, and it'll be exceptionally rare for you to have to disable the whole extension whenever you want things to get working again.