Except for Article 1 section 8. If it can be used to prevent a farmer from growing crops to feed his own animals, then it can be used to regulate insurance sales across state lines.
The current is moving in the opposite direction now. Female genital mutilation is now legal in America because federal courts have decided that it's better than abuse of the commerce clause: https://www.nytimes.com/2018/11/21/health/fgm-female-genital...
