CF Studio (Homesite's big brother) was my first thought. I used it for 10+ years before switching to OSX and even that Mac switch was many years ago. I'd guess CF Studio has been around for ~20 years and had FTP, site management, datasource interaction, etc.
PageMill is a contender too, from 1995. Dreamweaver in 1997. I remember using both of those in one of my first jobs.
PageMill doesn't have a real site manager, it only has a sidebar that shows the files of a folder, but doesn't know anything about the site's structure. It is really just a notch above Netscape Composer.
PageMill is a contender too, from 1995. Dreamweaver in 1997. I remember using both of those in one of my first jobs.