Ketamine is an NMDA antagonist, and there are other drugs in this class being developed as antidepressants. AXS-05 was granted "breakthrough therapy" status by the FDA and combines the NDRI bupropion with dextromethorphan which has effects similar to ketamine's. We really are in exciting times for antidepressants.
When I was younger, I've done dextromethorphan quite a bit, and while I was mostly doing it for the dissociative effect, it always had the side effect of lifting my mood for a couple of weeks afterwards
Well yeah, DXM is the drug people are drinking cough medicine for. Its called "Robotripping" when you take it. I believe most people just try to drink the cough medicine that is straight dextromethorphan, like robitussin, when taking it. The other ingredients, like the expectorant, in stuff like Nyquil would probably just make you sick drinking a lot of it... and i doubt the amount of alcohol in it is enough to have any noticeable effect.
