What kind of closed source / commercial software can be fuzzed on your platform? E.g. how would you fuzz something like Adobe Lightroom or Autodesk AutoCAD there? What kind of reports would you provide?
The nature of fuzzers like AFL is that you get better results by instrumenting your code and writing your own harness, but AFL has a "qemu mode" that runs precompiled binaries in an instrumented VM instead. We'll be adding this to the platform in the near future.
You won't get the same kind of results that you could by writing your own harness, but it would still be possible to find crashes, extreme memory usage or timeout bugs. Using something like libdislocator [1] would allow you to expose certain memory bugs as well.
