There is a bus that does that route. It follows El Camino (35-40mph most of the way) from San Jose to San Francisco. I used to take it as a broke college student and it was absolutely a last resort. Not only does it make dozens of stops but the bus is generally dirty and a hangout for transients. It ran 24/7 and took well over 2 hours each way, so homeless people would ride it basically all day.