I find games that try to depict real life suffering to often be too on the nose for the medium, but I love games that deal with themes like loss, grief, etc. through good story telling. Some indie games have done a really good job of this, even when it's not the focus. Celeste for example toes the line of being too on the nose in my opinion but is a great example of a game taking on a serious topic (anxiety.) Plenty of other examples out there.