This looks really nice. It's a shame the name is so similar to an existing app though (Pyxel Edit, https://pyxeledit.com/)
My favourite 2D framework right now is is LOVE (love2d.org) - I'm using that to build stuff with/for my kids and it's just a joy to use. I'll probably write up some parent/child friendly tutorials at some point. I also like Monkey-2 (http://monkeycoder.co.nz/), but I only really use that when I want to do basic 3D stuff, because Love does the 2D stuff so well...
I'd like to see your thoughts on Love. I've been using it for the past week and so far it's my favorite game-making environment (I've tried a lot of other tools).
I like being able to just sit down and code rather then spend hours trying to understand someone's gui with a bunch of tools I probably don't need for my tiny project. Never tried Lua before this and I'm finding it pretty comfy too.
Those are all unmaintained projects. pyxl4/pyxl4 and Dropbox/pyxl haven't been in a long time and pyxl4 says gvanrossum/pyxl3 is unmaintained and while gvanrossum/pyxl3 was updated a month ago, it was just the README. The code hasn't been updated in over two years.
My favourite 2D framework right now is is LOVE (love2d.org) - I'm using that to build stuff with/for my kids and it's just a joy to use. I'll probably write up some parent/child friendly tutorials at some point. I also like Monkey-2 (http://monkeycoder.co.nz/), but I only really use that when I want to do basic 3D stuff, because Love does the 2D stuff so well...