Ayahuasca is a South American brew consisting of two plants one consisting of a MAOI and another of DMT (the exact plant genus differs). DMT without a MAOI gets broken down by the blood brain barrier, so its not efficient without the MAOI.
The MAOI however puts dietary restrictions before the drug is being administered, and also makes the drug last vastly longer. Without the MAOI, the DMT wouldn't last long (IIRC even less long than Salvia). That might be an interesting use case.
Apart from that, there's all the time research on tryptamines [1] (MDMA, LSD, psilocybin, etc) used to treat mental diseases and personality disorders. The advantage synthetic drugs have is they're easier to standardise. I'm not sure why you'd want to research MAOI + DMT instead of the ones already mentioned? What advantages could it have over those?
I assume Ayahuasca refers to MAOI + DMT instead of merely DMT, but I could be wrong. Although which plants would be used as source? Maybe we should try to avoid the term Ayahuasca altogether; it is vague.
> Ayahuasca has a lot of bad side effects such as vomiting, sea legs, and diarrhea
Those are side effects which can occur; not side effects which will occur. Ie. possible side effects.
Its anecdotal and merely one experience as well, but I had no problem with diarrhea or vomiting. Sea legs, yes, which I knew beforehand. Hence I made sure I was able to lie down (which I did).
As a young adult in beginning of my 20s I've experimented with a plethora of other drugs as well, mostly psychedelics which back then were legally available, at least where I'm from (Ayahuasca is still legal here [1]).
Its been a good 10 years ago but during my experience with DMT + MAOI (self prepared, legally bought from a company called Azarius). From what I remember, I merely saw dragons in all kind of colours whilst lying down. I couldn't see through it just like you described. Auditory perception was vastly altered as well, akin to psilocybin, but with psilo I often lacked the visual aspect of 'tripping'.
The most anxious part of my consumption was the preparation because of the dangers associated with the MAOI. I carefully avoided everything except one cup of espresso a few hours before I started intake. I also didn't quit smoking (back then I was an average smoker). I had no hunger during my usage, though I don't remember the effect on my smoking habits. I wrote various trip reports for private usage back then and still have them, but either I didn't do it with the Ayahuasca one or it got lost.
In hindsight it wasn't very mature. I did extensive research on all of the drugs (A. muscaria was particularly fascinating) but did not always have a babysitter. I had a mild psychosis from cannabis at one point, and a few years later I was diagnosed with GAD and AvPD. Recently, this got reverted to a primary diagnosis of ASD (autism) instead. I also have schizophrenia in my family, though distant, and have memory problems. ASD has severe effects on sensitivity, thus could potentially be dangerous with psychedelics. Perhaps also worth noting that years after I quit recreative drugs usage I had one severe psychosis, triggered by stress.
DMT is extremely powerful and short-lived when taken via smoking or injection. It is interesting because it is an endogenous substance, and it is essentially the root of all of the related hallucinogens like Psilocybin or LSD - . Psilocybin is turned into psilocin, which is 4-hydroxy-N,N-DMT, and then DMT in your body shortly after you ingest it. Compare the chemical structure to LSD, too.
The MAOI however puts dietary restrictions before the drug is being administered, and also makes the drug last vastly longer. Without the MAOI, the DMT wouldn't last long (IIRC even less long than Salvia). That might be an interesting use case.
Apart from that, there's all the time research on tryptamines [1] (MDMA, LSD, psilocybin, etc) used to treat mental diseases and personality disorders. The advantage synthetic drugs have is they're easier to standardise. I'm not sure why you'd want to research MAOI + DMT instead of the ones already mentioned? What advantages could it have over those?
[1] http://psychedelic-information-theory.com/Psychedelic-Pharma...