If you really want to get fancy you could use Selenium to get screenshots and compare them to check that the remynified CSS produces the same layout as the original CSS.
To add to that point, if you manage to get screenshots you can do an image comparison using perceptual hashing [0]. The idea is to compute hashes of images and compare those, rather than scanning through each pixel.
Note that perceptual hashes should not obey the avalanche effect, so a minor difference in the two images should yield a small change in the hashes (desirable in this case). Then accept results that are within some small % error margin.
An example of a library that does this is jimp [1].
http://www.seleniumhq.org/