What is the technical use case for Wine these days? Are we basically talking running certain Windows applications on Linux, at reasonable framerates, using hardware that doesn't support full virtualization pass-through? In other words, if you've got virtualization support, and pcie pass-through support, why not just run this stuff through a Windows VM?
So I don't have to have the overhead of a full Windows virtual machine draining my laptop battery and filling my SSD with updates I didn't ask for to run the few windows-only applications I use.
I make extensive use of alt-tab. I have yet to find a smooth way to switch between applications running inside a VM and applications running outside the VM.
I also haven't found a way to achieve acceptable video performance inside a VM, short of dedicating a graphics card and doing a full PCI-E passthrough.
My one use case is that I have a legal copy of Photoshop 7.0 from the early 2000s that is my main image editing software that I'm still using on an almost weekly basis thanks to Wine.
It lets me run some of my favorite Window's programs like quickpar, winscp and windiff on my Mac without the bulk of a VM or requirement for a Windows license to run on that VM. I also don't have to maintain a Window's install.