Evernote, sqlyog, MS Office (for compatibility or the more sophisticated functionality of Excel). Adobe stuff I run on virtualbox. I have to use Playonlinux and certain versions of the products to make everything work right.
Even with Play On Linux [1] I've found it a lot of hassle to try and run games through WINE.
For example I had a whole set of Tom Clancy games (Ghost Recon, Rainbow Five, etc.) running through WINE. Of course I noted how I got them running on the WINE Appdb. Then a couple of years later needed to reinstall - had upgraded OS, changed video card, etc. - and spent ages trying but ultimately failed. WINE's db had been cleaned and removed my reports, handy; and PoL just wouldn't work (possibly the APU??) despite reports to the contrary.
Sad, when ones knows these things can work. Even sadder with more modern games when the distributor/producers won't mess with WINE so the player doesn't have to.
Some versions like Office XP won't work but Office 2003 does. Office 2013 will install using PlayonLinux but won't activate or update or load templates from the Internet.
Myself I find Libreoffice to be better than MS Office.
