If it has the potential to take down your site? Unless you have someone who can fill in for you, absolutely.
Really, it will come down to a cost/benefit analysis. Are your chances of the site going down due to being hacked over the weekend higher than the chances of a last minute update taking down the site?
The answer is almost always no (much to a sysadmin's chagrin). If the answer is yes (i.e. another heartbleed), then you are probably going to be working through the weekend anyways.
