One thing perhaps ISPs could do is share data on these attacks, and work to shut off the botnets after the fact- so they can't be used again. So for example if Akamai shared information with ISPs about which orgin IPs were involved in the DDOS attack, the ISPs could reactively reach out to the affected customers. Or the ISPs could even try to examine their own logs after hearing a report of a large scale DDOS attack to determine if any of their own nodes were part of it. There may be also measures ISPs cold take on their CPE routers to detect infected machines on the customer network and warn them more pro-actively.