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Slate star codex kind of speculates [1] that it might have something to do with scale, ie -- in order to keep growing in a creature that large, the cancer cells need to coordinate among themselves and specialize to a degree that is not needed at smaller scale. In other words, before the cancer can grow large enough to threaten the host, "the cancer gets cancer."

[1] http://slatestarcodex.com/2014/06/14/living-by-the-sword/

Speculation by a psychiatrist of course, and mostly in service to a metaphor about some totally other topic, but I wonder if there's something to the theory.




There is a lot of speculation in this area - see Peto's paradox [1] - what we are missing is lots of good data.

1. https://en.m.wikipedia.org/wiki/Peto%27s_paradox




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