The first time I saw her interviewed, 2-3 years ago, I knew it also. The incredibly unclear, defensive and meandering answers to incredibly simple questions, the strange confrontational body posture, the paper-thin hints at more business partnerships and customers than they could actually talk about...once I started learning about the makeup of the board and some bio friends of mine explained the non-homogeneous chemistry of blood, I confirmed it in my mind.

I still don't know of a convincing explanation for all of it, but it reminds me of some first and second-hand experiences I've heard about other, much smaller startups, in deep deep states of denial while the company is literally falling down around the CEOs head.