I don't really see any good from him speaking, at worst he will pull off a giant troll and his whole speech will be a flop, and at best he will be talking about 4chan's culture.
It's interesting, all up, the money making idea. Even though /b/ contains the best and worst of the net, the other boards are quite reasonable (as long a /b/ stays up to keep the trolls from wandering). Is the sites image so bad that advertisers can overlook such an opportunity for targeted ads? (ie. its unlikely anyone would be in the anime board if they weren't quite interested in anime)