...until it stops being enough, either due to gradual tolerance making them seek a stronger and stronger fixes, or due to something that disrupts production by the yeast-culture.

At which point they will seek the most sugary liquid ever.... The human brain.

Too much sugar in brains, you say...

> How should I know? I'm a dentist. But here's what I do know: If a tooth is bad, you PULL IT. Yep, mad brain's got to come out, boy!

https://www.youtube.com/watch?v=_JHaeJyLw2o