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Why are these trials organ specific? Lung cancer, pancreatic cancer, etc. Does it really matter?


Interestingly, this is a matter of debate right now: see "Forget lung, breast or prostate cancer: why tumour naming needs to change: The conventional way of classifying metastatic cancers according to their organ of origin is denying people access to drugs that could help them" https://www.nature.com/articles/d41586-024-00216-3

A number of companies have sprung up that'll try to a tumor sample to a variety of treatments in order to figure out whether treatments from other tumor sites may work better.

My own tumors originated in my tongue; now I don't have a tongue any more (https://jakeseliger.com/2023/09/09/life-swallowing-tasting-a...) and the tumors reside in my neck and lungs. A lot of oncologists who specialize in head and neck cancers also work in lung, since there seems to be a lot of overlap between the two.

I don't know this for sure, but I think DNA profiling is changing how oncologists, and people more generally, view cancers, or at least many cancers. Decades ago, it wasn't feasible to take molecular snapshots of cancers. Now it's still not quite standard, though it should be, via companies like CARIS: https://www.carislifesciences.com/


I just wanted to say that I sympathize with many of the things you describe in your linked post. I didn't have it anywhere near as rough as you, but: I had a motorcycle accident: I've felt the strange cold of a nasal feeding tube filling with the neon blue fluid food; I lost something like 35 pounds spending a month in the ICU; I've experienced both an NG tube going in and coming out, and how weird that feels -- same for removing a chest tube: it doesn't really hurt, it just feels wrong; I've had a catheter, so I know all about how wrong that feels; and of course I know about the constipation as well.

I've felt hopeless as they dialed back the ventilator prepping to take me off it, and I've been so weak I got stuck in the bathtub.

So: best of luck, and best of doctors to you.


I read your linked article, and I’m so sorry for what you went through and what you continue to live with. Two members of my immediate family were diagnosed with cancer within a month of each other. One didn’t make it as a result of just how punishing the adjuvant treatments were. She succumbed to an infection and couldn’t fight it off.

Being in the treatment rooms for both people made surgery, chemo, and radiation all feel like blunt instruments that crushed the patients. Even 3 months post treatment, my surviving family member suffers from the effects of the treatments, and likely will for up to a year we’ve been told.

I hope you get some relief and hope for your situation. Your writing is exceptional.


Cancer is cell-specific. Organs are made of different types of cells specific to that organ. Lung cancer is not the same as pancreatic cancer is not the same as breast cancer, etc. If cancer was not cell-specific, it would be much easier to synthesize treatments for.


>Organs are made of different types of cells specific to that organ.

I think I broadly agree but with the important caveat that organs frequently share cell types and therefore can share cancers specific to those cells, across organs.


They’re not organ specific, they’re disease specific. Despite all being called cancer, they’re not really the same disease and each variant might express different targets or react differently to the same treatment.


Cancer isn't one disease, any cell could potentially become cancerous and they can potentially become cancerous in different ways. A universal cancer vaccine will probably never happen, but hopefully we'll be able to have enough coverage of the more common ones such that cancer is effectively eliminated.


Yes. "Cancer" is over 100 different diseases, all with different pathologies: https://en.wikipedia.org/wiki/Cancer#Research


Perhaps because there is not one disease named cancer but many diseases sharing the same umbrella name.

After all, cells in each organ have often specific shape, receptors, behavior, means to communicate with other cells, etc...


The mutations and vaccine are usually specific to the type of cancer, so yes one treatment won’t help a different kind of cancer. Unfortunately, of course, but that’s the way it is.


Why can't people just admit they got super lucky and stay retired


"Don't be snarky."

"Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something."

https://news.ycombinator.com/newsguidelines.html


This is actually one of the more important functions needed for a free market to function. She's doing something we think is stupid and at the end of it the pot of money/influence she has will either be greatly diminished or she'll be right and get a massively larger pot for the next round. That she is doing this is a massive win for us because it is greatly in our interest for her to either prove she's awesome by enriching our lives with a much better product/service or for her to burn the piles of money she's accumulated before they are passed on to her kids (who are highly likely to be unimpressive, or have children that are unimpressive). Either we get a much better product/service or we get a much diminished time for her descendants to fail back to average, it's a win-win for society no matter which way this goes.


I don't know how much I'd agree with "much", given that's she's worth an estimated $600 million. At a paltry 5% apr, that's still $30 million a year in interest.


I never thought about it like that, thanks for the perspective.


It's what people don't get about the excesses of capitalism/free markets. They serve a function. We get massive productivity/research/business process gains of millions of people putting their money where their mouth is everyday and playing a repeated game for more money/size/ influence from providing a better solution. That only works if people are reasonably sure they will keep the gains from their risks/hard work so we can't just steal the proceeds from them before it gives outsized clout to their more than likely idiotic descendants. Instead we need it to be reasonably easy for them to lose their money in a way that doesn't deter future risk taking of everyone else, of which this is one way.

I actually think this function is the real reason it's so bad that Rehnquist kneecapped antitrust so badly in the 70's through 90's and we have a nation of oligopolies now. The oligopolies can exercise outsized market power and stay in existence for way longer than they would otherwise, which gives outsized and long lived returns to the idiotic offspring at the expense of pricing above marginal cost for society, which does harm us on every purchase via the higher price, but really harms us through keeping idiots in excess wealth that should have gone to some smart upstart, costing us decades of that upstart making wise choices.


I once asked my first boss - worth tens of millions - why don’t you just sell your company, and retire for good? Instead of working 10-12 hours, 6-7 days a week?

He simply told me that he’d go crazy from boredom, and that the business was his life. He loved the work, his clients, his employees, everything about it.

The man was on his second heart-attack, pending divorce, but that’s what he loved doing.

He’s now in his mid 60s, and still doing the same. Some people are just made to work.


I think I may be slowly turning into this (sans the tens of millions) and I don't really have as much problem with it as a younger me would have expected. My problem is more finding work that I think actually adds value to the world and doesn't cause me burnout. Turns out if I have work that doesn't destroy my soul, I'm willing to keep doing it; it's one of the main things keeping the nihilism from creeping in.


I had a discussion with someone in similar position. He implied that at a certain point it is about succeeding and keeping score, rather than about the money.

The people who would bail out and live on a beach are probably the kind of people who wouldn't have the success to do so. (I count myself amongst them.)


> Some people are just made to work.

I wonder if he would think of it as some people just are made to play, which in his case happens to align with what others call work...hence the tens of millions.


She is spending her own money and her rich friend's money to give her team a good salary and a chill work environment. I don't see a problem with that.


The not-so-cynical view would be that perhaps she enjoys building companies and leading product teams.


[flagged]


Why?


Well I suppose I’ll just head into your home, help myself then. Like I said, I enjoy free stuff.

As a radical truth seeker on a forum devoted to them (or so some have claimed anyway)…

Marisa Mayer is one of billions? What evidence can she put forward her status is not coupled to conservative politics heavily repeated by media?

Perhaps it’s all just dopamine and oxytocin addiction due to intentional propagation of conservative socio economic and political memes of the past, enjoyment, Schadenfreude, of worker deference?

As a radical truth seeker, I’m not content to accept such lazy and old social memes (it’s not 2006 anymore) as sacrosanct truth. Thats pseudoscience, living in a biological state the past we know is essential. It smells of religious conviction, banal stubbornness, laziness, and entitlement.

Will reality unzip if “this isn't the way”?

Goodhart’s law: Is “they enjoy it” a good enough measure to burn up resources on startup role-play? Is startup culture and hand wavy billionaires based upon conservation of dated (it’s not 1900s anymore) political rhetoric good enough?

As a Xennial it’s been interesting watching Boomers and GenX lose their energy for the future and replace it with demands of fealty to their past via social media.

Us radical truth seekers are not so content conserving past propaganda and success. “Commit it [conservation of past society] then to the flames…”


What?


There are lots of people who do think that way. You never hear about them again. You only hear about the minority who do take another swing.

Also, who’s to say she doesn’t “admit it”.

She can acknowledge her fortunate circumstances while still deciding she wants to spend her future building another company which may or may not succed


I’m not as “lucky” as her, but I can’t stay “retired” for more than 9 months. I’ve tried twice. It’s not even money, financially I have more than enough to retire now, I kind of just have to be doing something that I think isn’t bullshit, and I’m not ever going to get good enough at my hobbies to pursue them full time


Hunger drives people. For some it's the hunger for financial safety to cover their needs (housing, food, etc.), for other it's the hunger for being better than your previous self, or better than your peers/competition.

Truth be told, if you're all set in life - financially independent - and don't need to produce anything, it is incredibly easy to just become another dilettante.

Actually pursuing hobbies full time takes some serious discipline, because you really don't have any commitments - and can quit whenever you want, without any consequences whatsoever.

And, thus, for the vast majority - focusing on hobbies full-time can become a chore. You rarely (if ever) hear about retired rich people that become the very best in some field they see as their hobby.

At least with work, you have clients / customers. It's much easier to tell your boss "fuck you, I quit" once you have that kind of money - than to quit on your paying clients/customers.

Also, and this is just my observation, people seem to become (intellectually) duller real quick after they retire and don't do anything specific.


It’s not just a matter of commitment with hobbies either. I like Dream Theater and I play electric guitar. But try as I might I will never even come close to John Petrucci. It’s not even physically doable, although I’ve gotten pretty decent over the years. Whereas in my professional life I _am_ at the top of the food chain if I want to play ball. I just sometimes struggle to find an interesting game to play so to speak.


ZBiotics is a really exciting biotech startup that makes a GMO probiotic that digests Acetaldehyde, a byproduct of alcohol consumption that is a large part of hangovers. Personally think they reduce the effect of drinking by about 40%.

www.Zbiotics.com


The process is somewhat straightforward: - Search your full name, your username, your phone number, pieces of your last 3 addresses. - Check image search in particular For each result: - Google their remove me process and execute it, if they have one. - If not, find an email contact and ask nicely. Make up some excuse - If that doesn’t work, email a more formal GDPR right to be forgotten note if you are in EU. - If that doesn’t work, Google has a GDPR removal process if you are in EU.

Now wait 1-2 months and do it again. Now wait 1-2 months and do it again. ..

After about a year you should be able to reduce your surface area tremendously.


There are several businesses that claim to help with this process, including providing convenient links to those removal processes for many big entities. I cannot advise whether they are grabbing all your info too.


I like the guy, he seems like a genuine technologist / hacker. I wish him well.

None of the things he has worked on are any good so far. Objectively nobody actually uses this stuff. My definition: nobody would choose this stuff at arms length from a financial interest in pretending it is the correct technological + business choice.


> Objectively nobody actually uses this stuff.

Why did you use the word objectively here? It seems like people objectively do use this stuff, though you possibly don't think that they're actually getting value out of it. Ethereum likely has more users than anything either of us will ever build.


No meaningful percentage of the global population uses crypto and a large majority that do are bad actors, either in their use or their motivations for marketing it's "uses". Maybe "relatively" would have been better but the point is the same.


Is this the goalpost now? That a "meaningful percentage of the global population" uses your creation? That's a high bar.


For a currency that is not issued by a sovereign state and purports to be useful for day to day transactions and a hedge against inflation, that's not a high bar.

It would be a high bar for a currency whose purpose is to facilitate dark or illicit transactions, though.

Unfortunately the valuations seem to have been predicated on the former use case, not the latter


I have no idea what you're talking about. I'm assuming "your" means eth, which I'm not directly talking about in my response. I'm talking about the failure of crypto adoption that's original purpose was a fast, cheap and decentralized currency - none of which has come to fruition and by the looks of it, never will.


> Objectively nobody actually uses this stuff.

Objectively this is trivial to disprove.


Yep, just Uniswap alone has transaction volume comparable to major centralized exchanges.

https://decrypt.co/114665/uniswap-overtakes-coinbase-second-...


This is incorrect/misleading on many fronts:

1. This is an outdated article citing a single point in time

2. The source tweet is comparing Uniswap's volume on all x:ETH pairs against only ETHUSDT volume on centralized exchanges. [0]

3. The date of comparison is an outlier day - when FTX's "hacker" decided to move huge sums of tokens uneconomically on chain.

4. Volume across CEXs have collapsed, a sign of the ecosystem's weakness, not strength.

5. Even then, Uniswap doesn't hold a candle to Binance. ($600m volume vs $10b volume, past 24 hours on spot pairs)

6. Liquidity is horrible right now. If you try to execute a trade of reasonable size on a non-major coin you will face a lot of slippage.

[0]: The tweeter, Alex Svanevik is the founder of Nansen, a chain analytics company. It doesn't make sense that he would make such a simple mistake unless he was deliberately trying to bullpost.

See for yourself:

https://www.coingecko.com/en/exchanges/uniswap#statistics

https://www.coingecko.com/en/exchanges/binance#statistics

https://www.coingecko.com/en/exchanges/coinbase#statistics


Between bots, wash trading, and algo traders it doesn't say much about real world adoption.


Regarding wash trading at least, it's easier on central exchanges, since they can do it without cost. Nobody can avoid Uniswap's transaction fees.


> Objectively nobody actually uses this stuff.

Spoken with a privilege of a first-country citizen with a working banking system. I personally know dozens of people who use crypto for their main purpose: to transact. Without it, they wouldn't have been able to earn their living or have any access to their money.


I am based in Nigeria, a ‘third-world country’, I work remotely for a company domiciled in the US and get paid in Stablecoins (USDC & USDT). Crypto has been a life saver for me. Before that, one alternative was to get a USD account in a local bank & get paid via Western Union. The challenges are numerous. To setup a USD account locally takes a long time & multiple requirements. Assuming that hurdle is crossed, the more challenging issue is how restrictive Central bank policies are. In an economy with high inflation & parallel market rates for USD, there’s an incentive for the government to retain as much USD in the economy due to poor trade policies preventing $ revenues from coming in. Withdrawal limits have been reduced over the last 2 years alone, & the flexibility to make $ payments is hindered by low transaction limits with a USD card ($15 per transaction). To navigate this, I tried creating a virtual USD bank account with a local Fintech, with which to receive salaries. However these virtual accounts can only receive payments from US accounts (via ACH transfers) so can be restrictive. The most seamless solution to my problem has been to setup a crypto wallet. In minutes I receive my salary and can spend any amount, whenever I like. Plus, it makes it easier to save in USD, avoiding the local currency devaluation (The Naira has fallen 52% in the last 7 years under the current regime). So speaking as a ‘third-country citizen’, crypto provide a far more effective banking system.


I'm not questioning your experience but this is very strange to me.

I've worked with contractors based in Brazil, Turkey, and other countries likely categorized as "developing" and the payment process doesn't look any different than when I work with international contractors in places like Germany.

Many of them use Wise (formerly TransferWise) and looking at the pricing for Nigeria it looks completely reasonable - sending money has a 0.41% fee and receiving it is free. This fee includes reasonable things like a website non-crypto enthusiasts can actually use, customer support, fraud protections, etc. For countries with unstable currencies, massive inflation, etc Wise allows you to hold it in over 50 fiat currencies (including USD).

Given that I've had an interest in crypto for many years at this point I've seen online descriptions like yours so I've asked the contractors I've worked with "Why not crypto?". They all tell the same story - that services like Wise are perfectly usable and with extremely reasonable pricing all things considered. Wise even provides the sending of invoices that I (as the client) receive via e-mail and can pay in a few clicks. The most important thing to people is actually getting paid and it's a well known fact that reducing friction around payments is the best thing you can do (I've been a contractor as well).

Note this is technical/development contract work. I can't imagine people in non-technical fields getting an invoice asking for payment in crypto stablecoin and them spending the time, energy, and resources to wander through that maze to pay a contractor, service, etc instead of running their business. Frankly I'd use a different contractor and I'm very crypto literate.


Wise used to be a great option to transact in, 2-3 years ago. The main challenge with Wise however was the exchange rate used to convert USD received to the local fiat currency. In Nigeria there are two exchange rates - the first at an official rate used by banks, & the second a parallel rate used by the black market (including Bureau de Change operators).

Today if you Google the ‘official’ exchange rate for the dollar to Naira, you’ll see a ~445 Naira to 1 USD. As an individual there isn’t anywhere I can buy dollar at this rate, because it is exclusive to banks, select licensed money operators & politically connected high-net worth individuals. However money services like Wise convert my dollar at this official rate. Considering that the parallel market rate today is 745 naira to 1USD, I will be losing a huge amount of money by receiving money with Wise. The only workaround will be to get a virtual account on Wise & send USD to a local money merchant, who then exchanged at this parallel rate. But such virtual accounts aren’t accessible to people in Nigeria, due to regulation. [1] For context, the Central bank of Nigeria released a circular a while back explicitly stating Wise as a non-licensed entity.

There are other options apart from Wise. But the trade off is loss of money, as compared to what’s available on the parallel/black market.

[1] https://www.reuters.com/article/nigeria-money-idAFL1N2IX1BM


Thank you for the detailed education of the issues specific to Nigeria! But I'm still curious - can you explain how crypto transfers aren't subject to the same issues getting to Naira, the traditional banking system, etc? Getting solid data on the adoption of crypto for real day-to-day payments in Nigeria (or anywhere) is pretty difficult.

Genuinely curious.


Crypto transfers aren't subject to these issues because they aren't regulated. For instance, cards (Visa, Mastercard & Verve) can't be used to deposit on these exchanges because they'll have to be processed by a fiat operator, which usually requires a license. Because the government has banned the use of crypto, any entity caught wanting will have their accounts frozen. This also makes it really hard to deposit money into these entities by anyone. They can easily be blacklisted because they have accounts in their names. I used to work for one of such entities. I've also had my bank account frozen by the Central Bank of Nigeria for withdrawing naira that was sent from said 'blacklisted' entities.

Because these crypto exchanges are P2P based (e.g. Binance P2P), I can exchange my USDC for Naira that's deposited directly to my account. Because these are individuals, it's hard for the government to isolate bank transfers that are made for the purpose of crypto. For caution, people making such transfers tell each other not to add a description with a crypto-related word to these transactions.

Adoption for real day-to-day payments in low-volumes (like paying for groceries at a shop) is quite low, but high among high-volume merchants who import/export goods and are in dire need of USD liquidity and ease of payment across countries. Tough Central Bank policies give them an incentive to find the best rates & transact with lesser barriers. There are no official figures/solid data, because all that activity happens in informal channels (like P2P).


I don't understand though how do you explain those transaction to your tax authorities and pay taxes. Surely it can only be so long that you can get massive (by local standards) and fairly constant salary month to month and not get them interested in the source of funds?


I have family in developing countries but not Nigeria. Usually there's massive tax fraud that happens all the time regardless. Prevailing tax rates are punitive enough that nobody follows them and they're rarely enforced so there's elaborate reporting schemes that large portions of the moneyed population follow and is essentially accepted practice.


Yes, this is the case for Nigeria. Taxes mostly come from working individuals, which are deducted by the company before the net salary payment is sent. They also come from transactions. Companies are accountable to the government, but rarely individuals. Foreign companies with remote workers in Nigeria have to either pay to a USD account or pay via crypto. Crypto is untaxed because it is banned. USD in a bank account is subject to withdrawal limits & must be exchanged at the bank’s rate, which often 40-50% less than the parallel/black market rate. Crypto (USDC/USDT) is the only way to get the true Naira equivalent of the dollar. But it’s the most convenient way to receive payments & individuals get no tax-related penalties for it today.


As someone in Argentina, let me explain my situation:

As you pointed out, not many employers are willing to pay directly in crypto, that's why a lot of contractors - myself included - are willing to use platforms like Payoneer, Wise, even Paypal if there is no other option.

The missing part of the story here is how contractors in a developing country with currency controls, high inflation, poor banking infrastructure get the money -out- of those platforms. Most of the time you just cannot do it legally, so you end up "selling" your Wise/Payoneer/Paypal balance for the equivalent in the local currency. This is usually against their ToS and which can result in your account getting banned, losing access to your money (that's why it's advised to -not- leave any significant amount of money on these kind of platforms).

With crypto I also need to deal with black markets (which are always growing down here) and some business are starting to accept crypto directly (mostly tech-related busines). But, unlike these platforms, I actually have control over my money (it cannot be "confiscated" by my wallet unlike my Wise balance), fees are usually lower (ex. Payoneer results in a ~3.5% fee, Paypal ~10%, Wise ~1%, while in crypto - lets say BUSD - fees are mostly flat at around 1/2 USD at most), and market liquidity is higher (it's -a lot- easier to sell USDT/USDC/BUSD/DAI than your Paypal balance).


I am very curious of two things:

1. Are you actually transacting with others directly in USDC/USDT? I.e. are there shops where you actually buy things through your crypto wallet, or are you converting to USD/Naira and using that?

2. Are you self-hosting that wallet, or is it actually an account on some exchange?

Either way, I doubt that working remotely as an employee of US companies is a very common way of life in your country, so I don't think this supports the GP's point as much as it appears.


1. I transact with others in Naira, crypto is hardly a payment option in shops here.

2. I use an exchange to receive USDC, which mean I don’t need to worry about gas fees while self hosting

To get Naira, I convert from the exchange in a P2P marketplace where I can get competitive black market rates from other individuals.


> The Naira has fallen 52% in the last 7 years under the current regime

How much has crypto grown in Nigeria? Is it possible that the migration to crypto / loss of faith in the local currency in lieu of USD is what’s actually behind the collapse vs government policies themselves?


It's usually a combination of both. When the local currency is unreliable, as a result of bad government policies, the locals will try get hold of a stronger foreign currency. They will sell the local currency to buy the foreign currency, which will contribute to the depreciation of the local currency, which in turn will make it even less attractive, prompting more people to sell, and so on so forth.


Neat, in what kind of industry/countries have you seen this?


Russia, Ukraine and refugees from these countries all around the globe.


Russia doesn't have refugees, it has a tiny number of people seeking asylum after protesting against the regime. Middle class Russians fleeing conscription are not exactly comparable with people seeking refuge from Russian bombs, are they?


Uptake in Zimbabwe, Nigeria and a number of other African countries has been climbing


Maybe people should be clear that they meant it'd only be useful in the context of living in the "third world"?


Strange. How did anybody live there before 2015?


Ah yes here comes the privilege argument to derail legitimate discourse. You love to see it.

Your first approach should be a Wise multi-currency account.

Where Wise doesn't work the only thing that makes any sense are stablecoins from a proper issuer, like USDC (definitely not USDT). These are of course issued and controlled by centralized entities, making them antithetical to the very principles of crypto. They may as well be private scrip CBDCs.

Any decentralized/floating-rate coins are utter garbage for folks without access to meaningful banking systems in so-called third-world countries due to the volatility, embedded systemic leverage, high fees and potential long transaction times. These folks are the least able to stomach the 90% drawdowns (and 100% rug-pulls) we've seen market-wide. Frankly, I think the Turkish Lira has outperformed every major cryptocurrency for the last year.

What these people need are actual privacy-preserving CBDCs, of which there are exactly zero in the market.

Please put away the faux privilege defense. Folks of any level of privilege are able to comment meaningfully on the fitness of a technical system for purpose. Allow their arguments to stand on their own merits.


Although I agree that the expression that OP made maybe wasn't the best, they do have a point.

> Your first approach should be a Wise multi-currency account.

Excellent example; Wise is not available for account setup in the vast majority of developing countries, so if that's your solution it's already a failure. But why? For the most part it seems to come down to banking and currency regulations, which is exactly what cryptocurrency (at least Bitcoin) was designed to circumvent. I'm not even talking about countries that are essentially kleptocracies and have moulded their regulations to fit that structure, or remittances that have become such a large industry they practically power the GDP of a number of extremely poor countries.

> Any decentralized/floating-rate coins are utter garbage for folks without access to meaningful banking systems in so-called third-world countries due to the volatility, embedded systemic leverage, high fees and potential long transaction times.

I'm not sure this argument still holds with all the defi options today, but if this is an improvement on the status quo I guarantee people in third world countries will use it in spite of its deficiencies. A central bank that throttles access to alternative currency options will practically shut down the use of existing banking infrastructure, whether it's good or not.


> Wise is not available for account setup in the vast majority of developing countries, so if that's your solution it's already a failure.

Do you have a source for this? The closest thing I can find is this list of countries where it isn't allowed [0], which includes several developing countries but certainly not the vast majority of them.

[0] https://wise.com/help/articles/2978049/which-countries-can-i...


Personal experience attempting to open an account with them while living in a developing country. Granted, this was about 5 years ago so the situation may have changed since then.


> Wise is not available for account setup in the vast majority of developing countries, so if that's your solution it's already a failure.

I was ranking options from worst to best. Best would be something like Wise. Second-best would be a stable coin from an issuer that isn't an outright fraud. And last would be any floating-rate coin.

Last year Bitcoin literally hit transaction fees of 20% of the GDP per capita of the worst-off countries and then fell 75% in value. I wouldn't wish a system like that on my worst enemies let alone of people I claim to be trying to help. It was massively outperformed by the Lira. I can't even find one that wasn't outperformed by the Lira. It may have been designed to meet this need but it utterly failed by any measure.

USDC is a strictly better option. And better than that would be a USDC like system that preserves privacy issued by a central bank.

> I'm not sure this argument still holds with all the defi options today.

Literally 10% of the entire TVL of DeFi was lost last year to hacks and shows somehow no sign of slowing down.

The real privilege is believing that poor folks are as risk tolerant as you are in a first-world country and that this is somehow a better solution than a nice home-grown payment network like M-PESA.

It’s like a cocaine-powered ruined fresco of the financial system.


I thought ICOs had a chance to help small projects but unfortunately they became the worst of crypto. I don't blame the technology though. It's the "investors/ponzi hungers" that blew it.


It's inseparable from the technology. The technology is about issuing and transferring, and exchanging virtual tokens. This is all it does. And what can you do with virtual tokens? Not much, other than trying to sell them for money. I think Ponzis will always be one of the main use cases, if not the main use case.


fwiw, I use USDC transfers on Ethereum in preference over wire transfers (which for me seem to require a physical bank visit to clear) or Zelle (which has very low max limit per day).

I actually don't know of any robust alternatives in the US.


Playing with new technology and research is an important thing, but you have to be open that you are doing that and don’t pretend you are developing a usable product.


So what's the next hackernews? Anyone have a link?

Reason I ask is comments like this are objectively wrong yet continue to be the norm here.


He starts the article with an example of someone using Ethereum in their store


The son of a Russian computer scientist who cloned Bitcoin as a teenager definitely all by himself?


>Objectively nobody actually uses this stuff

Stay tuned for major central banks deploying CDBCs on ethereum. Swiss, EU and Singapore are launching a pilot program.


You can't claim something that large without a source. And why should governments pick Ethereum to enrich the bagholders with tax money?


This is interesting, but not great Japan advice. I just went and had a blast and did the opposite of his advice. I think people are different and want different things and don't feel bad if you just want to see the standard Japan checklist. His talk of everyone being surly..you know what, be respectful, everyone in Japan is so polite and nice that you will be happy with the level of service everywhere.

I've been many times and there is a time to venture out and there is a time to enjoy what everyone enjoys and both are fine.


Yeah, I have spent a year in Japan and visited most prefectures and disagree with the article. Of course you should get off the beaten path, but if you avoid it like the article recommends, you will have a much worse time.

Additionally, the advice to visit Gifu is terrible. I spent a week in and around Gifu-shi per Patrick's advice years ago and, while the area is charming as the article states, it is not somewhere you should visit before seeing a dozen other places.


Gifu is charming, but I don’t get this either. I had a friend there, so my experience is different, a good place to eat, hang out, not really a tourist place even with the castle (and you could see a better one in Osaka).


It reminded me of Milan: a lovely place to live, but a pointless place to visit as a tourist. And I'm at least a CEFR B1 in the language - it would be an atrocious place to visit if you have no Japanese. No clue why the article recommends it (except maybe as an attempt to establish credibility).


Ya, Milan was pretty bad. Got out to Genoa in one night when I realized it just wasn’t going to work out for more than a day.


The founders are done with each other and long gone. It's just a financial entity maximizing profit. It's amazing to watch the full circle of Google's brilliant birth to slow plateau.


Sustained profitable growth for nearly 24 years is the exception, not the rule.


What happened with the founders relationship?


It is how every company goes when it gets too big. It does feel like it’s plateaued.


If you would be relieved if anyone quit, fire them TODAY.


I wonder if this Ultrasound Directional Jammer would be the right mix of legal and proportionate.

https://www.tinytxs.com/products/ultrasonic-jammer


Gosh he's describing the Owlet which is an amazing device and I am glad exists and the FDA sure isn't


Why is FDA against the device? Honestly curious.


They didn't follow the laws that govern medical devices & were marketing it with claims they didn't have the support for: https://www.fda.gov/inspections-compliance-enforcement-and-c...


"Since 2016, the FDA has corresponded with Owlet that the Owlet Smart Sock meets the definition of a device under the FD&C Act and does not fall under the compliance policy for low-risk products that promote a healthy lifestyle (General Wellness guidance)."

Yikes it does seem that they were playing games with their marketing and stringing the FDA along.


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