I've had similar symptoms for 7+ years now so it's most likely for life. Have seen many infectious disease specialists and CFS/ME is the diagnosis (same as long-covid). Mine seems to have been triggered by Glandular Fever (Epstein Barr Virus).
Exertion is the biggest trigger for me, but also the prescribed cure (Gradual Exercise Therapy). Alcohol is a weird one, I often feel better with a hangover than I do on a bad fatigue day (immuno-suppressant?) but then way worse the days after. I also have recurring Mononucleosis symptoms and have tried anti-virals to no avail...
It's so obviously immuno-related, really hope the science progresses soon.
for those reading, GET is not a/the prescribed cure for mecfs, its contraindicated and is no longer broadly recommended (after a lot of controversy). It was once adopted as a recommendation but its the product of faulty science and a medical system that found the disease inconvenient and largely didn't want to treat/believe it
really sorry you're dealing w mecfs insaider, i feel your pain
If it is a meat dish, from India, it is far more likely to have been invented by Indians for the Brits living in India. Whether that makes it Indian or British I leave to others.
That's not true. Huge numbers of Indians aren't Hindu and do eat meat. Less than 40% of the country is vegetarian. There are meat dishes that pre-date the arrival of the British, although it's true that almost all Indian food has been altered by British colonialism.
>Huge numbers of Indians aren't Hindu and do eat meat.
Just in case anyone has the wrong idea (and I guess some people do), being Hindu does not equate to not eating meat.
Many Hindus eat meat (and many don't (though even that has nuances)), and have done so from ancient times, not just nowadays because of modernisation or westernization, although that has increased the percentage too, IMO.
Yum indeed! I also make sure to ask for an extra helping of the (dry) peanut chutney. That and the green chillies are must-haves with a vada pav for me :)
I've always heard it referred to as "Dana Chutney", Dana being a contraction of Shengdana.
I don't know if it's the same thing as Thecha, though -- but it does fit the description. I'm wondering if this is a geographical difference in culinary terminology :)
> And Portuguese colonialism. Practically all modern Punjabi food from makki to rajma is from South America.
Vindeloo is derived from Portuguese cuisine as well. In fact, the Portuguese are widely accredited with introducing spicy chili peppers into Indian cuisine.
Whats your thoughts on the dosage? They use 1g per kg of body weight! If I drank Monster to get the equivalent dosage I think I'd probably die... How did they arrive on that dosage?
That's because Monster has caffiene and other chemicals in there that may kill you! The Taurine itself probably won't kill you as LD50 is 5g per kg of body weight
LD50 should be taken with a huge grain of salt for any compound. First of all LD50 is just the dose required to kill half the subjects within some short time frame. Long term toxicity is not captured by this number. And doses well below LD50 can still kill you.
Also, because you can't overdose humans with drugs until half of them die(in most jurisdictions...), the number is pretty much always based on animal experiments. And it's quite typical for some things to be wildly more toxic in certain species than in others.
Crucially, a dose of 1g/kg has never been tested in humans in the short or long term.
I'd be very hesitant to say that 1g/kg is unlikely to kill a human being based on LD50 being 5g/kg. It could very well have an unacceptably high risk of death, or long term toxicity.
Also, please don't make statements like this based on LD50 unless you're absolutely sure. Someone who understands even less about it might look at it and thnk "this guy seems to know his stuff", and then do something stupid.
While the mouse example of 1000mg/kg is ridiculously high, the monkey trial used 250mg/kg.
Assumption time: assume a 67kg human who consumes 3 cans of redbull a day (not especially unusual). they are ingesting 9000mg (total) per day, which comes out 135mg/kg. Given the easy availability of Taurine supplements in almost any pharmacy it’s not a stretch to see this pushed significantly higher.
Added to the above, this was an initial trial, and it’s very possible the therapeutic levels of Taurine supplementation may be significantly lower (there appeared to be a correlation of health and life extension between the mice and monkeys even with the significant difference in dosages) it’s very possible that the 3 can of red bull dosage is efficacious. Of course that could be mitigated by the high levels of sugar and caffeine but that is outside of the scope of this conversation.
To summarize : 250mg/kg was efficacious in monkeys and no lower bound was determined, it’s possible the amount of Taurine in 3 cans of redbull (assume 9000mg) per day is within the clinically effective range.
Trials like these usually use herculean doses like this. If you remember, the "aspartame can kill you" trials also used an incredible amount of aspartame to kill the mice.
What if you actually asked the students what they think the best approach is? I wonder what they'd have to say when confronted with optimizing their own education.
As a CS grad I often felt such a large percentage of the syllabus was legacy theory I'd (mostly correctly) never need. Perhaps this can be the positive impetus to get teachers to really rethink syllabuses from a more practical, useful view point. "here students, use ChatGPT and all the tools available to you to create x..."
