Have you looked at Really Right Stuff and Kirk Enterprises, they are machining the parts you are making, basically a sick release plate. But they are now ubiquitous enough that I would hate to see yet another quick release style. Never been a fan of the large ManFrotto/Bogen style. Take a look at the two aforementioned, I think they take a cue from Arca/Swiss, and are some of the nicest designs in quick releases that I have seen.
Thanks for your comment but why would you "hate" to see another design?
We're not creating a whole new system, just an alternative. And as a start we will be Mamfrotto compatible only, since that's what we use. I could be wrong but Kirk doesn't do Manfrotto at all.
If I read correctly, this was staged out on a single core user machine, then pushed out to an Amazon 16 core machine. Not the most powerful either, and no mention of any tuning. They mentioned looking to hit max scale out by simply adding more machines. Which is why they mention going from 20MG -> 100 -> 1000 not being an issue. In theory, wire speed is their limitation before they have to look at other methods. At 1000MB/s you could start chunking your data into result sets in advance, taking the time it takes a human to read the results visually as always being the bottleneck, and using that time to your advantage, to make the user think the app returns answers instantly all the time. I can't imagine 1000MB/s ever being too slow when you factor in their current dashboard and what it is returning. More complex dashboards and things certainly will need reworking.
Opiates will cure depression, stop it dead in it's tracks for a large majority of people. Good luck finding a Dr to help you down that road though. There is a reason people have an illicit drug of choice, and that is a good indicator of what anti-d's may work best for you.
Opiates, you are screwed, meth, there is Adderal or Ritalin, ( All these probably have had their names changed by now to something else ), if you like cocaine, then an SNRI may be better for you. Anxiety, ideally they lighten up and give you a benzodiazepine, more than likely you will get a med that was initially a smoking cessation medication.
Psychiatry is a black art, I really almost feel unless you are clinically depressed, schizophrenic, etc, if you are going to be a human medicine dart board, don't, be a human health dartboard. Exercise, diet, etc, but be insanely specific, insanely calculative in what you do if you choose the non-med way, as it is just as much a mystery as are the pills.
Worse, keep in mind that pill, broke perfect in half, will not have equal amounts of the active or inactive ingredients in each side. Further, if it is a generic, it doesn't even have to have the same mg amount of the active ingredient, only within a margin of something like 90%, which is huge when dealing with these types of meds.
Presumably because patented drugs don't have any bioequivalent drugs to compare to and the margin of error is based off of how different the generic is from the original. Originals do have stricter regulations on the amounts of inactive fillers used though.
> Most regulators worldwide have decided that a 20% variation is generally not clinically significant.
>Two versions of a drug are generally said to be bioequivalent if the 90% confidence intervals for the ratios of the geometric means (brand vs. generic) of the AUC and Cmax fall within 80% and 125%. The tmax (brand vs. generic) must also be comparable — and there should not be any significant differences between different patients.
Anyone who tells you anti-depressants are not habit forming is a rep for a pharma co. that has not been sued to change their stance on that statement yet.
Habit forming - addiction - tends to include tolerance (doesn't exist for anti depressants), pre-occupation (doesn't exist), drug seeking and holding (doesn't exist).
There are problems with anti depressants being over prescribed and misprescribed to people who should have had a talking therapy, and they are difficult for some people to stop, but calling them hanit forming is incorrect.
Wouldn't the withdrawls qualify them as habit forming? Calling them extremely addicting would probably be inaccurate, but "There's a good chance you'll feel awful if you stop taking this" seems like it may encourage forming a habit.
>ADT tachyphylaxis incorporates drug sensitivity as a potential causal factor for the decreased response. However, tolerance provides a more accurate explanation. While the exact cause of ADT tachyphylaxis in individual cases is unknown, drug tolerance is a more comprehensive model, as it includes mechanisms of pharmacodynamic tolerance, metabolic tolerance, and others.[7]
I suspect you need not go that slow. I am NOT a Dr., but have talked at length with mine about this. I won't go into specifics or detail as people need to talk to their Dr.s about these methods.
All meds have a half life, your taper rate will be based on that and your personal metabolism rate, which can and almost always is altered by the meds themselves.
Further confused that a huge percentage of people who suffer depression need no meds and instead need a thyroid test, and not just a "give blood and see where you were at that moment" test, but a real, pain in the butt, complicated test, which I suspect is why they don't give them as a first line test. I was blown away I was never offered one.
As you get down to the lower doses, it gets harder, some you will have to take to a compounding pharmacy, others you can crush and get a good scale and weigh out what milligram or microgram you need; others, if you feel safe doing so can be taken intranasaly via a Flonase sprayer depending on if the med is water soluble and what the mixed shelf life is, which can be hard data to get at times.
I can say there is no worse kick than Effexor, that is for damn sure, and that was only 2-3 weeks in. That had a permanent change on me for life, instilling a bit of timidness in me regarding certain things that happened as I was detoxing.
Good Luck, hope you get off them and manage to learn how to manage your life without them, that is exactly where I am as well. They work, but I don't like the fake happy feeling. They try to tell me that is what my normal is, and I am just not remembering my true normal, that I don't buy, I remember my youth before this all started.
effexor, aka venlafaxine, gave me some amazingly horrible vertigo if I missed more than 1 dose in a row. I was off antidepressants for about 2 years, and then I was hit with severe depression. I'm on the generic for paxil now, and it has made a huge difference. The impact was a night and day contrast.
Someone I know who took it said they got what they could only describe as "head shocks" - the effect of small pulses of electricity flowing through their brain during withdrawal.
We don't really care that much about the OS -- never did, never will. A windows license is very cheap, and we only need maybe 20 windows licenses to run the whole network.
The much bigger cost are SQL Server licenses, for which we care very much about!
All in all we'll keep on using SQL, but on the most performant platform -- my bet is that it's going to be Windows for a while though.
Regarding .Net Core: the platform is not ready yet (e.g. lack of support for Security IIRC), but we'll adopt it when it is -- again on the fastest platform.
Both in the case of SQL Server and .Net core, we are working publicly on GitHub with Microsoft by testing and providing advice where needed to make sure the next version of our ecosystem is the best possible.
Their web/service tier are still windows, doesn't seem that likely that they'd rewrite them in .netcore fast enough to be off windows completely in the near future.
