Was he by any chance hanging out with a crowd of people "detached from reality and pure reasoning", or consuming media written or recorded by people detached from reality and pure reasoning? Psychedelic use is associated with reinforcing personality traits related to openness to new ideas and "absortion". So do naturally occurring religious experiences. It's a tale as old as humanity, it's not the altered brain chemistry alone, it's the setting.
You can definitely overdo psychedelics and fuck up your mind if you are careless with them. Maybe read up a bit on erowid, dmtnexus, shroomery, plenty of warnings from people who went to deep. Don't be stupid and naive.
Microdosing may seem harmless, but it also means taking psychedelics every day for long periods. I wouldn't do more than 2 weeks, you gotta have to function without the drug at some point, can't imagine dosing LSD for a year and then stopping will be pleasant. But your mileage might vary... I just have way to much respect for psychedelics to take them every day.
I always find phrases like "detached from reality" in discussions about psychedelics to be somewhat ironic. I mean, I know what meaning you intend, but the phrase itself is a bit suspect if interpreted literally.
I've seen a friend of mine going deeper and deeper into that hole.